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The principal cytochrome P450 isoenzyme concerned seems to generally be CYP2E1, with CYP1A2 and CYP3A4 as more pathways. About eighty five% of the oral dose appears in the urine within just 24 several hours of administration, most as being the glucuronide conjugate, with smaller quantities of other conjugates and unchanged drug (see OVERDOSAGE) for